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In our previous report, the water extract of Bupleuri radix showed the lowering effect of total cholesterol level in the experimentally induced hyperlipidemic rats. In order to elucidate the active ingredient(s), the water extract were dialyzed, ad two fractions, high molecule fraction and low molecule fraction, were obtained. These two fractions were tested on the experimentally induced hyperlipidemia in rats for lowering effect of serum lipoprotein contents. Hyperlipidemia was induced on male Wistar rats by feeding high cholesterol diet for 7 days. After oral administration of above samples for 4 weeks, serum lipids profile was monitored by measuring total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol level. Low molecule fraction decreased total cholesterol and triglyceride levels significantly (p<0.05) at 4 week point when they were compared with the control group.
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